Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke

Summary

The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:

1. What regions of the brain's sensory systems show changes in their activity related to speech?
2. To what extent do these regions help listeners detect and correct speech errors?
3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?

Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).

Conditions

• Stroke
• Cerebellum

Interventions

BEHAVIORAL

Neural responses to speech functional localizer

Measuring speech-related brain activity using fMRI during a speech listening task.

BEHAVIORAL

Neural responses to silent articulation

Measuring speech-related brain activity using fMRI during a silent articulation task.

BEHAVIORAL

Neural responses to self vs. externally generated speech

Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.

BEHAVIORAL

Event-related potentials for speech

Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech

BEHAVIORAL

Neural responses to induced speech errors

Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.

BEHAVIORAL

Neural responses to sensory-motor adaptation

Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.

BEHAVIORAL

Speech production behaviors

Behavioral measurements of speech during reading passages and words

BEHAVIORAL

Auditory acuity testing

Measurements of auditory acuity during listening tasks.

BEHAVIORAL

Neural responses to learning a non-speech auditory motor behavior

Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.

Sponsors & Collaborators

• Northwestern University

  collaborator OTHER

• National Institute on Deafness and Other Communication Disorders (NIDCD)

  collaborator NIH

• University of Pittsburgh

  lead OTHER

Principal Investigators

• Jason W Bohland, Ph.D. · University of Pittsburgh

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-05-27

Primary Completion

2028-07-31

Completion

2028-07-31

Countries

• United States

Study Locations