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Long-term Survival Outcomes of Total Thyroidectomy and Radioactive Iodine Therapy in Unilateral T3/T4 FTC

NCT06437873 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2957

Last updated 2024-05-31

No results posted yet for this study

Summary

This study aims to thoroughly examine survival disparities in patients with T3 or T4 stage follicular thyroid carcinoma (FTC) as classified by the AJCC staging system. It compares outcomes between those who underwent total thyroidectomy (TT) and those who did not, and assesses the influence of radioactive iodine therapy (RAIT) on the survival of patients without TT. Utilizing the SEER database, a retrospective study identified patients diagnosed with T3 or T4 FTC, categorizing them into two cohorts: those treated with TT and those who were not (No-TT). The No-TT group was further analyzed to determine the impact of RAIT on patient survival. Propensity score matching (PSM) was applied to adjust for confounding variables. Survival analysis, including Kaplan-Meier survival curves and Landmark analysis, was conducted to evaluate the effects of surgical intervention and RAIT on overall survival (OS) and cancer-specific survival (CSS).

Conditions

  • Follicular Thyroid Cancer
  • SEER Database Analysis

Interventions

PROCEDURE

Total Thyroidectomy (TT)

TT:Surgical removal of the entire thyroid gland.

RADIATION

Radioactive iodine treatment(RAIT)

RAIT:Administration of radioactive iodine to eliminate remaining thyroid tissue or cancer cells.

Sponsors & Collaborators

  • Dezhou Hospital Qilu Hospital of Shandong University

    lead OTHER

Principal Investigators

  • Tao Zhang, MD · Dezhou Hospital Qilu Hospital of Shandong University

Eligibility

Min Age
5 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2000-01-01
Primary Completion
2020-12-31
Completion
2024-05-25

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06437873 on ClinicalTrials.gov