Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women

Summary

Type of Study: Clinical Trial

Goal: The goal of this clinical trial is to investigate specific brown and beige fat cells in the dorsocervical area of young, lean adult women.

Participant Population/Health Conditions: The study will involve 40 young, lean adult women.

Main Questions: The main questions this study aims to answer are:

* Are there active brown or beige adipocytes in the subcutaneous fat of the dorsocervical area (i.e., iBAT)?
* What is the secretory function of these adipocytes?
* How do traditional interventions like cold exposure, as well as new approaches like Beta-2 agonist stimulation and exercise, affect the thermogenesis of these fat cells at the cellular and molecular levels?

Participants Will:

Be randomized into one of four groups: thermoneutral exposure, cold exposure, aerobic exercise, or Beta-2 agonist treatment.

Follow their assigned regimen for 4 weeks. Provide tissue samples from the dorsocervical area and abdomen before and after the 4-week intervention.

Undergo analysis of these samples using advanced techniques to understand the presence and activity of brown and beige fat cells.

Comparison Group: Researchers will compare the effects of different interventions (thermoneutral exposure, cold exposure, aerobic exercise, Beta-2 agonist treatment) on the presence and thermogenesis of brown and beige fat cells in the dorsocervical area.

Conditions

• Cardiometabolic Diseases

Interventions

BEHAVIORAL

Thermoneutral condition

Participants will be exposed 2 hours/day at 32ºC for 5 days/week

BEHAVIORAL

Cold condition

Participants will be exposed 2 hours/day at 18ºC for 5 days/week

BEHAVIORAL

Aerobic exercise condition

Participants will perform aerobic exercise training 5 days/week at 65% heart rate reserve for 60 minutes each training session

DRUG

Salbutamol

Participants will take salbutamol 12 mg/day. 7 days week

Sponsors & Collaborators

• Leiden University Medical Center

  collaborator OTHER

• ETH Zurich (Switzerland)

  collaborator OTHER

• Universidad de Almeria

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

22 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-11-01

Primary Completion

2025-08-31

Completion

2026-08-31

Countries

• Spain

Study Locations