MedTrace Logo

Microbial Adhesion and Biofilm Formation on Denture Base Materials

NCT06395116 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2024-05-01

No results posted yet for this study

Summary

Polymethylmethacrylate (PMMA) has been the material of choice for fabricating complete dentures for more than 80 years now.(1,2) As a material it is easy to handle and can be easily repaired and polished. PMMA while being a low-cost material has good esthetics. Some disadvantages of PMMA as a material are surface roughness and porosities which lead to staining, plaque accumulation and bacterial adhesion over time.

Among the various factors that can influence microbial attachment to surfaces, surface roughness, hydrophilicity and free surface energy of PMMA are most important. Carboxylate and methyl ester groups found in PMMA make it a very hydrophilic material with a large amount of free surface energy. Despite the influence of the chemical composition, processing methods play the most important role in developing surface roughness.

Conditions

  • Inflammatory Response
  • Microbial Colonization
  • Denture Stomatitis

Interventions

OTHER

Denture base material

Denture base material constructed with different techniques for completely edentulous populations

Sponsors & Collaborators

  • Tanta University

    collaborator OTHER

  • Misr University for Science and Technology

    collaborator OTHER

  • Menoufia University

    lead OTHER

Principal Investigators

  • Mohammed A. El-Sawy, PhD · Menoufia University

Eligibility

Min Age
30 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-20
Primary Completion
2024-07-04
Completion
2024-09-05

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06395116 on ClinicalTrials.gov