MedTrace Logo

Mechanisms of Acute Kidney Injury in Severe Infections

NCT06372444 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 15

Last updated 2024-12-06

No results posted yet for this study

Summary

Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.

Conditions

  • Sepsis
  • AKI - Acute Kidney Injury
  • Positron Emission Tomography (PET)

Interventions

RADIATION

Positron emission tomography (PET)

Assessment of blood flow with marked water and assessment of neutrophil presence with neutrophil elastase tracer + CT

Sponsors & Collaborators

  • Uppsala University Hospital

    lead OTHER

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-01
Primary Completion
2026-04-03
Completion
2026-06-30

Countries

  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06372444 on ClinicalTrials.gov