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Brown Adipose Tissue Activity in Gilbert's Syndrome

NCT06336369 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2024-03-28

No results posted yet for this study

Summary

The goal of this case-control study is to investigate energy metabolism and brown adipose tissue (BAT) activity in individuals with Gilbert's syndrome (GS) and controls. The main focus of the study is to analyze:

1. the link between bilirubin metabolism and metabolic health.
2. energy metabolism and body composition in individuals with Gilbert's syndrome and control subjects
3. brown adipose tissue activity in Gilbert's syndrome and healthy controls.

Participants will undergo the following investigations:

1. cold exposure
2. PET-CT imaging with 18-F-FDG
3. MRI imaging of liver, abdominal fat and muscle
4. blood sampling
5. indirect calorimetry
6. bioelectrical impedance analysis
7. infrared thermography

Researchers will compare individuals with GS and control subjects in terms of metabolic health, body composition and BAT activity.

Conditions

  • Gilbert Syndrome

Interventions

DIAGNOSTIC_TEST

analyzing brown adipose tissue, body composition and metabolic health

cooling procedure, PET-CT imaging, MR imaging, blood sampling, indirect calorimetry, thermograpy, impedance analysis

Sponsors & Collaborators

  • University of Vienna

    collaborator OTHER

  • Griffith University

    collaborator OTHER

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Karl-Heinz Wagner, Univ.-Prof. Mag. · University of Vienna

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-03-06
Primary Completion
2027-01-15
Completion
2027-01-15

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06336369 on ClinicalTrials.gov