Effects of Differences in Body Composition on Retina and Choroid

Summary

The goal of this observational study is to examine the effects of body composition differences on retinal and choroidal structures. The study aims to investigate how variations in fat distribution and body composition parameters influence ocular microvascular structures.

The main questions it aims to answer are:

* How do differences in body composition (BMI, waist circumference, bioelectrical impedance parameters) affect retinal and choroidal microvascular structures?
* Are there significant structural changes in the retina and choroid among individuals with different body composition profiles?

Participants will:

* Be classified into five groups based on their Body Mass Index (BMI) (underweight, normal weight, overweight, obese, and severely/morbidly obese).
* Undergo detailed body composition analysis using bioelectrical impedance analysis (BIA) to assess fat mass, muscle mass, visceral fat index, and metabolic age.
* Receive comprehensive ophthalmologic evaluations, including Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA), to measure retinal thickness, choroidal thickness, and microvascular parameters.
* OCTA images will be analyzed using the OCTAVA software to compute vascular parameters.

This study does not involve any new treatments, drugs, or interventional procedures. The findings aim to provide insights into the relationship between body composition and ocular microvascular health, contributing to early detection and prevention strategies for obesity-related ocular complications.

Conditions

• Obesity
• Obesity, Morbid
• Body Composition

Interventions

OTHER

Optical Coherence Tomography (OCT) and Body Composition Analysis

This observational study included non-invasive diagnostic assessments to evaluate retinal, choroidal, ocular, and body composition parameters. Optical Coherence Tomography (OCT) measured macular and peripapillary retinal parameters, including retinal volume and cup/disc ratio. Enhanced Depth Imaging OCT (EDI-OCT) assessed choroidal thickness and vascularity, while Optical Coherence Tomography Angiography (OCTA) analyzed vessel density and foveal avascular zone (FAZ) metrics. Optical biometry measured axial length, anterior chamber depth, lens thickness, K1, K2, and central corneal thickness. Autorefractometry and tonometry were part of the routine ophthalmologic examination, including slit-lamp biomicroscopy. Bioelectrical impedance analysis (BIA) assessed body composition, including BMI, fat percentage, muscle mass, and metabolic age. These assessments were for research purposes only, without therapeutic intervention.

Sponsors & Collaborators

• Bayram Meydan

  lead OTHER

Principal Investigators

• MURAT KAYA, Prof. Dr. · Duzce University Faculty of Medicine, Department of Ophthalmology

• BAYRAM MEYDAN, MD, Research Assistant · Duzce University Faculty of Medicine, Department of Ophthalmology

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-07-01

Primary Completion

2024-10-01

Completion

2025-01-01

Countries

• Turkey (Türkiye)

Study Locations