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Little Cigar Oxidants

NCT06310187 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-04-08

No results posted yet for this study

Summary

Determine the effects of little cigars on human exposure to tobacco smoke oxidants. In a balanced randomized cross-over study design in cigarette smokers, subjects will be assigned to 3 exposure groups. These include a high oxidant little cigar exposure condition, a low oxidant little cigar exposure condition, and their usual cigarette. Biological samples will be collected before and after product usage.

Conditions

  • Tobacco Use
  • Oxidative Stress

Interventions

OTHER

High Oxidant Little Cigar

Subjects will be given a high oxidant little cigar to use for outcome measure data collection in the lab before and after product usage.

OTHER

Low Oxidant Little Cigar

Subjects will be given a low oxidant little cigar to use for outcome measure data collection in the lab before and after product usage.

OTHER

Usual Cigarette

Subjects will use their own cigarette for outcome measure data collection in the lab before and after product usage.

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Milton S. Hershey Medical Center

    lead OTHER

Principal Investigators

  • Joshua Muscat, Ph.D. · Penn State Hershey College of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-23
Primary Completion
2029-08-31
Completion
2029-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06310187 on ClinicalTrials.gov