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Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

NCT05658471 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2026-03-27

No results posted yet for this study

Summary

This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine users.

Conditions

  • Nicotine Dependence
  • Tobacco Toxicity
  • Cardiovascular Risk Factors

Interventions

OTHER

Standardized Research E-Cigarette (SREC)

Standardized Research E-Cigarette (SREC) will be obtained through NJOY, LLC and provided at the hospital stay.

OTHER

Over the Counter E-Cigarette (EC)

Usual brand e-cigarettes will be provided at the hospital stay.

BEHAVIORAL

Biological Samples

Blood, urine, and expired carbon dioxide will be obtained during the course of the study.

OTHER

Smoking-related Questionnaires

Nicotine and Smoking behavior and dependence questionnaires will be administered at screening, before and during hospital stays.

Sponsors & Collaborators

Principal Investigators

  • Neal Benowitz, MD · University of California, San Francisco

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2026-01-31
Completion
2026-01-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05658471 on ClinicalTrials.gov