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Efficacy of Hyaluronic Acid Injection in Knee Osteoarthritis

NCT06279507 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 176

Last updated 2024-02-28

No results posted yet for this study

Summary

The aim of this clinical trial study is to compare the efficacy of Hyaluronic injection in patients with symptomatic knee osteoarthritis. The main questions it aims to answer are:

* Is Hyaluronic acid injection improve pain symptom, joint stiffness, and joint function in patients with knee osteoarthritis
* Is Hyaluronic acid injection improve knee performance status and health-related quality of life in patients with knee osteoarthritis

Participants will be allocated to receive one treatments; either Hyaluronic acid or normal saline injections after receiving glucocorticoid injection.

Researchers will compare the Hyaluronic acid with normal saline injection to see if the former show superior effect in terms of pain, joint stiffness, function, as well as health-related quality of life comparing with placebo.

Conditions

Interventions

DRUG

Sodium Hyaluronate

Sodium hyaluronate 2% (40 mg/2 mL), with molecular weight of 1-2 million dalton Other active ingredient : Mannitol 0.5% Preparation : Pre-filled syringe

DRUG

Normal Saline

0.9% sodium chloride 2 mL prepared in plastic syringe

DRUG

Triamcinolone Acetonide 10mg/mL

10 mg of triamcinolone acetonide will be injected to all participants before the specified intervention

Sponsors & Collaborators

  • Chulalongkorn University

    collaborator OTHER

  • Khon Kaen University

    collaborator OTHER

  • Police General Hospital

    collaborator OTHER

  • Phramongkutklao College of Medicine and Hospital

    lead OTHER

Principal Investigators

  • Nis Okuma, Medical · Phramongkutklao College of Medicine and Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-10
Primary Completion
2025-01-31
Completion
2025-06-30

Countries

  • Thailand

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06279507 on ClinicalTrials.gov