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The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics

NCT00778076 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2009-04-01

No results posted yet for this study

Summary

The purpose of this study is to determine the impact of a regular course of treatment with Hyaluronic acid (HA) injections on gait in knee osteoarthritis (OA) patients. Three consecutive HA injections will be compared to three consecutive placebo injections to determine whether HA's analgesic effect is greater than that of a placebo injection, and to observe whether HA's viscoelastic properties are manifested in a human knee OA population. We hypothesize that HA injections will relieve pain to a greater extent than placebo injections in knee OA patients, and will afford them with improved walking characteristics, such as increased walking speed, and step length.

Conditions

  • Osteoarthritis, Knee

Interventions

DEVICE

Hyaluronic acid

3 consecutive injections, each one week apart, of 20mg/2ml Hyaluronic acid.

DEVICE

Placebo (Saline injection)

3 consecutive injections, each one week apart, of 20mg/2ml of Placebo.

Sponsors & Collaborators

  • University of Western Ontario, Canada

    lead OTHER

Principal Investigators

  • Robert J Petrella, MD, PhD · The University of Western Ontario

  • Joseph E DeCaria, BA, MSc('09) · The University of Western Ontario

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-07-31
Primary Completion
2009-05-31
Completion
2009-05-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00778076 on ClinicalTrials.gov