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Prospective Trial: Acute Myocardial Injury After Radical Prostatectomy

NCT06273735 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2026-02-03

No results posted yet for this study

Summary

This prospective observational study investigates the incidence of acute myocardial injury after radical prostatectomy for prostate cancer. Consecutive patients undergoing elective open or robot-assisted radical prostatectomy at the Martini-Klinik are included. High-sensitivity cardiac troponin I (hs-cTnI) is measured preoperatively and on postoperative days 1 and 2 to identify acute myocardial injury, defined according to the 4th Universal Definition of Myocardial Infarction. Secondary outcomes include the incidence of myocardial infarction, major adverse cardiac and cerebrovascular events, and mortality during the hospital stay and at 24 months. Baseline patient characteristics (age, BMI, cardiovascular risk factors including the Revised Cardiac Risk Index, comorbidities, and prior cardiac therapy) as well as surgical and tumor-specific parameters are recorded. Associations between acute myocardial injury and clinical variables are analyzed.

Conditions

  • Myocardial Injury

Interventions

DIAGNOSTIC_TEST

Pre- and postoperative determination of troponin as part of the study and 24-month FU survey

An intervention is carried out as part of the normal clinical procedure regardless of the study measurement parameters.

Sponsors & Collaborators

  • Universitätsklinikum Hamburg-Eppendorf

    collaborator OTHER

  • Martini-Klinik am UKE GmbH

    lead OTHER

Principal Investigators

  • Markus Graefen, Prof. · Martini-Klinik am UKE GmbH

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-08-14
Primary Completion
2024-02-28
Completion
2025-08-26

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06273735 on ClinicalTrials.gov