Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries- PreTerm

Summary

The goal of this multicenter, cluster-randomized, crossover trial is to determine if umbilical cord milking compared to early cord clamping will reduce in-hospital mortality in non-vigorous preterm infants born between 30 weeks and 34 weeks of gestation.

Conditions

• Preterm
• Infant Death

Interventions

PROCEDURE

Umbilical cord milking

At delivery, the umbilical cord is grasped, and blood is pushed toward the infant 4 times before the cord is clamped. This procedure infuses a placental transfusion of blood into the infant and can be done in 1--15 seconds.

Sponsors & Collaborators

• Thrasher Research Fund

  collaborator OTHER

• Thomas Jefferson University

  collaborator OTHER

• Sharp HealthCare

  collaborator OTHER

• Jawaharlal Nehru Medical College

  collaborator OTHER

• Daga Memorial Maternity and Children's Hospital, Nagpur, India

  collaborator UNKNOWN

• Mahatma Gandhi Institute of Medical Sciences, Wardha, India

  collaborator UNKNOWN

• Indira Gandhi Government Medical College & Hospital, Nagpur, India

  collaborator UNKNOWN

• Pimpri Chinchwad Municipal Corporation's Post-Graduate Institute, Yashwantrao Chavan Memorial Hospital, Pune, India

  collaborator UNKNOWN

• Government Medical College, Nagpur

  collaborator INDUSTRY

• Government Medical College, Chandrapur, India

  collaborator UNKNOWN

• Osmania Medical College, Niloufer Hospital, Hyderabad, India

  collaborator UNKNOWN

• Nemours Children's Clinic

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

0 Minutes

Max Age

10 Minutes

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-07-01

Primary Completion

2026-06-30

Completion

2026-12-30

Countries

• India

Study Locations