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Intrauterine Growth Restriction and Intrauterine Fetal Death

NCT07031583 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2025-06-22

No results posted yet for this study

Summary

This study investigated whether delaying the clamping of the umbilical cord after birth can reduce harmful oxidative stress in newborns, especially in those who did not grow well during pregnancy (intrauterine growth restriction - IUGR). By comparing early and delayed cord clamping in 90 newborns, researchers found that delayed clamping improved antioxidant protection and reduced signs of oxidative damage. These benefits were more significant in babies with IUGR. The results suggest that delaying cord clamping could help support better early health outcomes in vulnerable newborns.

Conditions

  • Intrauterine Growth Restriction (IUGR)
  • Oxidative Stress in Neonates
  • Umbilical Cord Clamping Time

Interventions

PROCEDURE

Delayed Umbilical Cord Clamping (DCC)

The umbilical cord was clamped between 60 and 180 seconds after birth or after the cessation of cord pulsation, in accordance with WHO recommendations. This procedure allows for additional placental transfusion and potential enhancement of neonatal antioxidant capacity.

PROCEDURE

Early Umbilical Cord Clamping (ECC)

The umbilical cord was clamped within the first 60 seconds after birth. This represents the standard or traditional approach used for comparison with delayed clamping in terms of oxidative stress outcomes.

Sponsors & Collaborators

  • Kayseri City Hospital

    collaborator OTHER_GOV

  • Istanbul Arel University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
0 Hours
Max Age
1 Hour
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-11
Primary Completion
2025-06-01
Completion
2025-06-02

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07031583 on ClinicalTrials.gov