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The Effect of Delayed Cord Clamping and Milking on the Amount of Stem Cells In Preterm

NCT04057027 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2020-05-07

No results posted yet for this study

Summary

Stem cell therapies have been promising therapies in neonatal morbidities such as bronchopulmonary dysplasia, intraventricular hemorrhage and hypoxic ischemic encephalopathy. Although researchers showed those effects by several mechanisms including paracrine effect, regenerative and restorative effects, there is no obvious recommendations for the type of stem cells, dosage or the route of administration the cells. The usage of exogenous stem cells can be difficult due to technical issues in preterm infants.

In the presence of these data, the amount of endogenous stem cells passing through the cord to the infant may show differences in terms of delayed cord clamping and milking. Therefore the aim of this prospective randomized study is to determine the quantity of the stem cells according to delayed cord clamping or cord milking. We also aimed to evaluate the association between the number of stem cells and neonatal morbidities.

Conditions

  • Umbilical Cord; Clamping Time

Interventions

PROCEDURE

Delayed umbilical cord clamping

During the C section, infants' umbilical cord clamping will be delayed for 30-60 seconds.

PROCEDURE

Cord Milking

Umbilical cord will be milked from th distance of 20cm from mother's side to the baby, for 3-4 times.

Sponsors & Collaborators

  • Turkish Neonatology Society

    collaborator OTHER

  • Kanuni Sultan Suleyman Training and Research Hospital

    lead OTHER

Principal Investigators

  • Seda Yilmaz Semerci · Kanuni Sultan Süleyman Eah

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Max Age
30 Minutes
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-15
Primary Completion
2020-09-05
Completion
2020-10-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04057027 on ClinicalTrials.gov