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Exercise Effects on Brain Health and Learning From Minutes to Months

NCT03114150 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 122

Last updated 2025-08-13

Study results available
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Summary

Given the accelerating growth of older adults worldwide and the decline in cognitive function with aging, therapeutics that remediate age-related cognitive decline are needed more than ever. The proposed research seeks to better understand and enhance the detection of exercise effects on hippocampal network function and learning and memory, which decline with aging and Alzheimer's. Success would lead to new ways to detect benefits of exercise on cognitive aging and would lead to mechanistic insight on how such plasticity is possible while also informing prevention strategies.

Conditions

  • Sedentary Lifestyle

Interventions

BEHAVIORAL

Cardiorespiratory fitness training

Physical exercise of moderate intensity designed to improve cardiorespiratory fitness

BEHAVIORAL

Functional fitness training

Physical exercise of light intensity designed to improve functional fitness

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • Michelle W. Voss

    lead OTHER

Principal Investigators

  • Michelle W Voss, PhD · University of Iowa

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
55 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-05-01
Primary Completion
2023-06-21
Completion
2023-06-21

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03114150 on ClinicalTrials.gov