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Bace1as Role in Heart Failure (BACE1AS-HF)

NCT06213493 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 630

Last updated 2025-04-30

No results posted yet for this study

Summary

The objective of this project is 1) to explore the clinical relevance of BACE1-AS and BACE1 as therapeutic targets and 2) to evaluate their potentiality as biomarkers in ischemic heart failure (HF).

The first aim will be studied by validating in left ventricle biopsies in patients with post-ischemic heart failure the transcriptome and DNA methylation status data obtained in cell lines where the expression of BACE1-AS has been modulated.

The investigation of BACE1-AS and BACE1 as biomarkers will be obtained by using peripheral blood mononuclear cells (PBMCs) from patients with acute coronary syndrome (ACS) treated with percutaneous angioplasty (PCI) procedure and undergoing to left ventricular remodeling. Furthermore, PBMCs from patients with chronic ischemic HF recruited from the Istituti Clinici Scientifici Maugeri Pavia will be also used. From the data obtained from these patients and from non-decompensated subjects, the levels of BACE1-AS and BACE1 in the blood will be measured and correlated with each other and with β-amyloid levels (βA), as well as with clinically relevant parameters.

Conditions

Interventions

DIAGNOSTIC_TEST

measurement of RNAs

RNAs will be measured in heart tissues and in peripheral blood mononuclear cells

Sponsors & Collaborators

  • Istituti Clinici Scientifici Maugeri di Pavia

    collaborator UNKNOWN

  • IRCCS Policlinico S. Donato

    lead OTHER

Principal Investigators

  • Fabio Martelli, PhD · IRCCS Policlinico S. Donato

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-12
Primary Completion
2024-11-30
Completion
2024-11-30

Countries

  • Italy

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06213493 on ClinicalTrials.gov