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Impact of Gravity on Cardiac Hemodynamics

NCT06190756 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2025-03-26

No results posted yet for this study

Summary

The goal of this clinical trial is to define and compare pre-load dependance of the cardiac function according to the intracardiac hydrostatic gradient of pressure in healthy and diabetic populations.

Participants will undergo 4 tilt angle and 4 lower body negative pressure intensities during which cardiovascular data will be assessed and a transthoracic echography will be performed.

Conditions

  • Diabetes type1
  • Healthy

Interventions

OTHER

Cardiovascular and Baroreflex stimulation by Tilting

Tilt of the patient at 4 angles (22°, 42°, 58° and 80°), the order is randomized for 3 angles (22°, 42°, 58°) while 80° will always be last.

OTHER

Cardiovascular and Baroreflex stimulation by Lower Body Negative Pressure

The patient will undergo 4 level of LBNP (10Torr, 20Torr, 35Torr, 50Torr), the order is randomized for 3 intensities (10Torr, 20Torr, 35Torr) while 50Torr will always be last.

Sponsors & Collaborators

  • INSERM UMR-S 1075 COMETE, Caen, France

    collaborator UNKNOWN

  • CNRS UMR 5220 INSERM U1294 CREATIS ,Université Lyon 1, INSA Lyon, France

    collaborator UNKNOWN

  • Jozef Stefan Institute

    collaborator OTHER

  • University Hospital, Caen

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-22
Primary Completion
2025-06-22
Completion
2025-10-15

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06190756 on ClinicalTrials.gov