Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies

Summary

Left ventricular obstruction is an invalidating complication of hypertrophic cardiomyopathies (HCM), and endothelial dysfunction has also been observed in these pathologies. However, the relation between obstruction and endothelial and venous dysfunctions has not been previously studied.

The main objective is to investigate the relations between endothelial and venous dysfunctions and symptomatic left ventricular outflow-tract obstruction in HCM patients.

Conditions

• Hypertrophic Cardiomyopathy
• Endothelial Dysfunction

Interventions

BIOLOGICAL

BNP blood sample test

Performed during normal recommended follow-up of the HCM patients.

DIAGNOSTIC_TEST

Electrocardiogram

Performed during normal recommended follow-up of the HCM patients.

DIAGNOSTIC_TEST

Holter ECG

Performed during normal recommended follow-up of the HCM patients.

DIAGNOSTIC_TEST

Echocardiography

Performed during normal recommended follow-up of the HCM patients. Echocardiography at rest and during exercise.

DIAGNOSTIC_TEST

Air venous plethysmography

Performed specifically for the research. Non invasive, and non painful test evaluating different parameters of venous filling by inflation of an armband around the leg, upright positioning, flexion-extension of the leg. Total duration estimated at 30-45 minute.

DIAGNOSTIC_TEST

Upper member arterial Doppler echography with analysis of FMD

Performed specifically for the research. Measurement of the evolution of brachial artery diameter before and after inflation of a armband during 5 minutes. Non invasive and non painful test, duration 30 minutes.

BIOLOGICAL

Endothelial function biomarkers

Performed specifically for the research. Blood sample test, 5 minutes.

Sponsors & Collaborators

• Fédération Française de Cardiologie

  collaborator OTHER

• Fondation Bordeaux Université

  collaborator UNKNOWN

• Amicus Therapeutics

  collaborator INDUSTRY

• University Hospital, Bordeaux

  lead OTHER

Principal Investigators

• Patricia REANT, MD · University Hospital, Bordeaux

Study Design

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-10-22

Primary Completion

2021-12-14

Completion

2021-12-14

Countries

• France

Study Locations