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Multimodal Vasopressor Strategy in Septic Shock

NCT06155812 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 79

Last updated 2026-03-31

No results posted yet for this study

Summary

The goal of this prospective randomized controlled trial is to compare the effects of classic stepwise vs. early balanced multimodal vasopressor strategies in septic shock.

Conditions

  • Shock, Septic

Interventions

OTHER

Simultaneous administration of vasopressors

Early, simultaneous administration of norepinephrine, angiotensin II, and vasopressin.

OTHER

Successive administration of vasopressors

Administration and titration of norepinephrine and vasopressin. Administration of additional vasoactive drugs (epinephrine, methylene blue, angiotensin II or dopamine) as per clinical team. Initiation of inotropes (dobutamin, levosimendan, milrinone) as per clinical team decision.

Sponsors & Collaborators

  • University Medical Centre Maribor

    lead OTHER

Principal Investigators

  • Žiga Kalamar, MD · University Medical Centre Maribor

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-12-23
Primary Completion
2025-12-31
Completion
2026-02-01

Countries

  • Croatia
  • Slovenia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06155812 on ClinicalTrials.gov