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The Role of Histamine in Muscle Protein Synthesis Following Resistance Training

NCT06152497 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2023-12-13

No results posted yet for this study

Summary

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Conditions

  • Histamine

Interventions

DRUG

Placebo

Oral placebo

DRUG

H1 blockade: Telfast: 180mg Fexofenadine

H1 blockade: oral blockade with 180mg Fexofenadine

BEHAVIORAL

Resistance training

Resistance training: lower body exercise

Sponsors & Collaborators

  • Research Foundation Flanders

    collaborator OTHER

  • University Ghent

    lead OTHER

Principal Investigators

  • Wim Derave, Professor · University Ghent

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06152497 on ClinicalTrials.gov