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Histamine H1/H2 Receptors and Training Adaptations

NCT04450134 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2024-06-07

No results posted yet for this study

Summary

Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Conditions

  • Exercise Training
  • Physical Activity

Interventions

OTHER

Lactose

Placebo: Lactose capsules

DRUG

Fexofenadine Hydrochloride

H1 receptor antagonist: 540 mg Fexofenadine Hydrochloride

DRUG

Famotidine

H2 receptor antagonist: 40 mg Famotidine

OTHER

High-intensity interval training (HIIT)

6 weeks HIIT

Sponsors & Collaborators

  • Research Foundation Flanders

    collaborator OTHER

  • University of Copenhagen

    collaborator OTHER

  • University Ghent

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-10-02
Primary Completion
2019-12-18
Completion
2021-04-14

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04450134 on ClinicalTrials.gov