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Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle

NCT05131555 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2024-04-12

No results posted yet for this study

Summary

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses a twofold research question: "What is the influence of endurance training (1) and histamine H1 and H2 signaling (2) on the gene expression in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Conditions

  • Exercise
  • Histamine

Interventions

DRUG

Placebo: Placebo + exercise training.

Oral placebo Exercise training: Interval-based cycling exercise

DRUG

H1 blockade: H1 receptor antagonist + exercise training

H1 blockade: oral blockade Exercise training: Interval-based cycling exercise

DRUG

H2 Blockade: H2 receptor antagonist + exercise training

H2 blockade: oral blockade Exercise training: Interval-based cycling exercise

Sponsors & Collaborators

  • Research Foundation Flanders

    collaborator OTHER

  • University Ghent

    lead OTHER

Principal Investigators

  • Wim Derave, Professor · University Ghent

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-08-16
Primary Completion
2021-12-06
Completion
2021-12-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05131555 on ClinicalTrials.gov