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Analysis of Cellular Kinases and Aging in PBMCs and Colorectal Tissue

NCT06132386 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 21

Last updated 2025-12-24

Study results available
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Summary

The goal of this clinical study is to learn about the effect of aging on certain enzymes, or proteins, in the blood and colon. The study involves collection of blood and colon tissue biopsies using a flexible sigmoidoscope or colonoscope. This study is also investigating how medications tenofovir and emtricitabine interact with certain enzymes. The investigators will compare the difference in enzyme activity between people taking tenofovir and emtricitabine, to those who are not taking tenofovir and emtricitabine.

Conditions

  • HIV Infections
  • Aging

Interventions

OTHER

biopsy

colorectal biopsy for tissue acquisition

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • National Institute on Aging (NIA)

    collaborator NIH

  • Johns Hopkins University

    lead OTHER

Principal Investigators

  • Craig Hendrix, MD · Johns Hopkins University

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-08-07
Primary Completion
2024-05-20
Completion
2024-05-20

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06132386 on ClinicalTrials.gov