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Tfh Dysfunction in HIV and Aging

NCT04487041 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 400

Last updated 2026-05-20

No results posted yet for this study

Summary

The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people to understand how aging and HIV infection affect the immune responses (body defenses against infection) to the flu vaccine.

Conditions

  • Human Influenza

Interventions

BIOLOGICAL

Standard dose influenza vaccination

Single 0.5 ml injection administered intramuscularly into participant's deltoid muscle

BIOLOGICAL

High dose influenza vaccination

4 times more concentrated single 0.7 ml injection administered intramuscularly into participant's deltoid muscle

Sponsors & Collaborators

  • University of Miami

    lead OTHER

Principal Investigators

  • Savita Pahwa, MD · University of Miami

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-10-30
Primary Completion
2026-06-30
Completion
2026-12-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04487041 on ClinicalTrials.gov