Accelerated Aging, HIV Infection, Antiretroviral Therapies

Summary

The main goal is to confirm, among HIV1-infected patients, data from in vitro studies showing that antiretroviral therapies induce an accelerated aging through the same mechanisms than genetic laminopathies or than "physiological " aging, that is through the synthesis and persistence of farnesylated prelamin A. The secondary goal is to measure the impact of HIV infection and of antiretroviral therapies on markers of cell ageing (proteasome, mitochondria, telomere). The perspective is to fix antiretroviral therapy side effects using the same drug combination that will be used in few weeks in Marseille to treat children suffering from progeria

Conditions

• HIV Infection
• Aging Accelerated
• Antiretroviral Therapies

Interventions

BIOLOGICAL

Peripheral blood biological tests

A group and B group will be evaluated three times, at baseline, then every 12 months during 3 years. In case of initiation or changing of antiretroviral therapy, patients will be evaluated once more. Control subjects will be only evaluated at baseline.

Sponsors & Collaborators

• French National Agency for Research on AIDS and Viral Hepatitis

  lead OTHER_GOV

Principal Investigators

• Isabelle POIZOT-MARTIN · CHU Sainte Marguerite -Marseille

• Marie-Pierre DROGOUL · CHU Sainte Marguerite -Marseille

• Olivia FAUCHER · CHU Sainte Marguerite -Marseille

• Amélie MENARD · CHU Sainte Marguerite -Marseille

• Joëlle MICALLEF-ROLL · CHU Timone

• Jacques REYNES · CISIH CHRU Gui de Chauliac- Montpellier

• Pierre DELLAMONICA · CISIH CHU Nice

• Pierre CAU · INSERM UMR S910 MARSEILLE

• Catherine TAMALET · Laboratoire Virologie Marseille

• Bruno LACARELLE · Unité INSERM U911 Marseille

• Nicolas LEVY · Laboratoire Génétique Moléculaire Marseille

• Patrick ROLL · Laboratoire biologie cellulaire Marseille

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2009-04-30

Primary Completion

2010-04-30

Completion

2012-03-31

Countries

• France