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The Physiology of Circulatory Arrest in Humans

NCT06130033 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2024-11-13

No results posted yet for this study

Summary

The purpose of this study is to better understand what happens in the brain during the dying process.

This is a prospective observational study conducted at the end of life in the ICU at VGH. At the time of withdrawal of life sustaining therapies the investigators will monitor brain blood flow and oxygenation. The investigators will also collect blood samples to measure biomarkers of brain dysfunction.

This may help us to determine when blood flow to the brain stops and when brain function ceases. This information may provide researchers and the medical community as a whole with important information as to the best timing for organ donation. This study is the first step in commencing a research program related to improving the organ donation process. Our goal is to determine how best to provide high quality organs to those who would otherwise die without an organ transplant.

Conditions

  • Circulatory Arrest

Interventions

DEVICE

Neuromonitoring

Multimodal Neuromonitoring: Transcranial Doppler - middle cerebral artery blood flow velocity Jugular venous bulb oximetry - hemoglobin oxygen saturation at the jugular venous bulb Arterial blood pressure monitoring - mean arterial, systolic and diastolic pressure monitoring at the radial artery via an in situ radial arterial line catheter Pulmonary artery catheter - to measure continuous cardiac output and mixed venous oxygen saturation Near infrared spectroscopy - to measure regional cerebral saturation of oxygen

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Mypinder S Sekhon, MD PhD · University of British Columbia

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-01
Primary Completion
2026-06-01
Completion
2026-06-01

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06130033 on ClinicalTrials.gov