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Proteomic Profiling to Reveal Novel Prognostic Markers for Neurological Outcome Following Resuscitation

NCT01960699 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 96

Last updated 2020-02-24

No results posted yet for this study

Summary

Background: Cardiac arrest is a life-threatening event. Intensivists are challenged with an increasing number of patients with uncertain neurological outcome following cardiopulmonary resuscitation (CPR). The prognostic value of current biomarkers for neurophysiologic long-term outcome is limited.

Hypothesis: We hypothesize that specific brain-derived tissue leakage proteins can be identified to reveal novel, more reliable prognostic biomarkers for good neurological outcome.

Methods: This translational study (n=100) is a combination of a prospective basic science study intended to reduce the number of potential plasma biomarker candidates by proteomic shotgun analyses in brain tissue autopsy samples and plasma samples from resuscitated patients (n=10) and a prospective clinical validation study in a large study population (n=90) by high-throughput analyses. Selection of proteomic markers and signature estimation will be performed to discriminate patients with good and poor outcome.

Clinical perspective: A structured proteomic analysis approach might identify the best marker out of all proteins liberated during cellular damage.

Conditions

  • Cardiac Arrest With Successful Resuscitation

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Christopher Adlbrecht, MD · Medical University of Vienna

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-10-31
Primary Completion
2020-01-31
Completion
2020-01-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01960699 on ClinicalTrials.gov