Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging

Summary

The goal of this behavioral clinical trial is to learn how to increase physical activity in mid-life adults. Specifically, can guided imagery that includes creating mental pictures increase excitement about working out.

Participants will be asked to complete testing at the beginning of the study, following 6-weeks of an in-person exercise program, and 6-weeks after finishing the exercise program. Testing will include an exercise test, MRI, questionnaires, computer tasks, and a blood draw.

Conditions

• Exercise Training
• Aging

Interventions

BEHAVIORAL

Episodic Future Thinking

During the audio recorded guided imagery exercise participants will be asked to think in detail of a future (6 months to a year) where they have made healthy choices regarding physical activity and are physically active.

BEHAVIORAL

Episodic Recent Thinking

During the audio recorded guided imagery exercise participants will be asked to think about a routine weekly activity.

BEHAVIORAL

Positive Affective Imagery

During the audio recorded guided imagery exercise participants will be asked to think in detail about the positive outcomes and sensations associated with an exercise bout.

BEHAVIORAL

Neutral Affective Imagery

During the audio recorded guided imagery exercise participants will be asked to think in detail about the physical sensations associated with an exercise bout.

BEHAVIORAL

HIIT Exercise Intervention

The high intensity interval training (HIIT) will be conducted 2 times per week for 6 weeks. The duration of each individual exercise session will last about 45 minutes. After the 5-minute warm-up at 30% peak workload, HIIT will consist of repeated 1-minute high intensity bursts ("on" interval) alternated with 1-minute interval recovery ("off" interval) for 25 minutes. The "on" interval will begin at 80% of peak watts (range: 75%-85%) followed by the "off" interval at 10% of peak watts. The session will end with up to 10 minute cool-down at 20% peak workload.

Sponsors & Collaborators

• National Institute on Aging (NIA)

  collaborator NIH

• University of Kansas Medical Center

  lead OTHER

Principal Investigators

• Laura Martin · University of Kansas Medical Center

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

FACTORIAL

Eligibility

Min Age

45 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-02-23

Primary Completion

2027-05-31

Completion

2027-05-31

Countries

• United States

Study Locations