MedTrace Logo

High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans

NCT05625204 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2025-12-12

No results posted yet for this study

Summary

Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems. Frailty leads to poorer physical performance and functional capacity and higher risk of adverse outcomes including falls, hospitalization, and mortality. Resilience, defined as the capacity to recover from disruptions to homeostasis, is critical to successful aging because it precedes frailty and enhances adults' ability to maintain optimal health and function well into older age. Evidence- based therapies to help older adults enhance resilience are limited and the biological underpinnings contributing to improved resilience have not yet been fully characterized. To address this important need, the investigators will conduct a clinical trial to examine the benefits of center- and home-based high intensity interval training (HIIT) on functional capacity, frailty, and resilience, and also to identify novel biomarkers of resilience in older Veterans.

Conditions

Interventions

BEHAVIORAL

Center based attention (stretching only) control

Center based attention (stretching only) control

BEHAVIORAL

Center based HIIT

Center based HIIT

BEHAVIORAL

Home based HIIT

Home based HIIT

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Bruce R. Troen, MD · Kansas City VA Medical Center, Kansas City, MO

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-29
Primary Completion
2027-07-01
Completion
2027-09-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05625204 on ClinicalTrials.gov