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The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA

NCT06112548 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-03-19

No results posted yet for this study

Summary

This interventional study aims to compare the effectiveness of local multimodal drug periarticular injection in TKA patients with the standard pain control regime that includes opioids, NSAIDs, and other analgesics.

The main questions The investigators strive to answer are:

Is there a significant difference in the severity of pain and functional outcomes when applying periarticular injections? Are there any increased complications when applying the periarticular injections?

Conditions

  • Arthritis Knee
  • Pain
  • Arthroplasty Complications

Interventions

PROCEDURE

primary unilateral TKA

Primary unilateral total knee arthroplasty with cruciate scarifying cemented DePuy Synthes PFC Sigma prosthesis.

DRUG

Bupivacain

low body weight (0.50%, 20cc) intraoperative periarticular injection

DRUG

ketorolac

1ml of 30mg/ml ketorolac intraoperative periarticular injection

DRUG

epinephrine

0.5ml Adrenaline 1mg/ml intraoperative periarticular injection

DRUG

Paracetamol

IV Paracetamol \[Ofirmev\] introduced every 6 hours after surgery

DRUG

Ketorolac

IV Ketorolac {Toradol} introduced every 12 hours after surgery.

DRUG

Tramadol

IV Tramadol \[Ultram\] introduced when needed after surgery

Sponsors & Collaborators

  • Damascus University

    lead OTHER

Principal Investigators

  • jaber ibrahim, MD PHD · Damascus university - faculty of medicine - department of surgery

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-03-01
Primary Completion
2025-11-01
Completion
2025-11-30

Countries

  • Syria

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06112548 on ClinicalTrials.gov