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Somatic Mosaicism in Twins Discordant for Childhood Cancer

NCT06054295 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-12-16

No results posted yet for this study

Summary

Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.

Conditions

  • Pediatric Central Nervous System Tumor
  • Central Nervous System Tumor
  • Discordant Twin
  • Somatic Mutation

Interventions

OTHER

Biospecimen collection

Collection of both blood and saliva samples from participants at the time of study enrollment

OTHER

Questionnaire Administration

The brief questionnaire will assess health history, demographics, environmental exposures, family history of cancer, and birth characteristics.

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Children's Oncology Group

    lead NETWORK

Principal Investigators

  • Jenny Poynter, PhD · University of Minnesota

Eligibility

Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-03
Primary Completion
2026-06-30
Completion
2027-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06054295 on ClinicalTrials.gov