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Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios

NCT00155506 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2005-11-28

No results posted yet for this study

Summary

Schizophrenia is a chronic and devastating major psychiatric disorder. Family, twin, and adoption studies indicated that schizophrenia has a significant genetic component. The mode of transmission is still not clear and a multilocus model was proposed. The location of susceptibility gene of schizophrenia is still under active search using molecular genetic methods.

We propose to collect genomic DNA and lymphoblast cell lines of a total of 150 DSM-IV schizophrenic patients and their first degree relatives including parents (parent-offspring trios) and non-affected siblings in three years. Adequate statistical power of molecular genetic studies is a great concern. For this concern, we will examine the patients and their parents clinically by using the Diagnostic Interview for Genetic Studies (DIGS) for diagnostic assessment, and by using neuropsychological battery including sustain attention, executive function, verbal memory and general intelligence for neuropsychological evaluations.

The project is feasible because (1) The PI and his research team have experience in successfully collecting co-affected sib-pair families of schizophrenia and in setting-up molecular genetic laboratory in the past decade. We are experienced and competent to execute this project. (2) The PI and his research team have established the instruments using to clarify the phenotypes including the DIGS, the neuropsychological battery these years.

Major goals of this project are: (1) to cooperate with this important Taiwan Genotype Consortium proposed by the NHRI; (2) to detect major schizophrenia susceptibility genes related to the neuropsychological endophenotype; (3) to do further fine mapping on suggestive linkage markers to replicate previous linkage studies results using our previously-collected co-affected sib-pair family sample; and (4) to deposit the lymphoblast cell lines into NHRI Cell Bank serving as a national resource for basic research in Taiwan.

Conditions

Sponsors & Collaborators

  • National Taiwan University Hospital

    lead OTHER

Principal Investigators

  • Hai-Gwo Hwu, Professor · National Taiwan University

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-11-30
Completion
2004-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00155506 on ClinicalTrials.gov