Amplification of Positivity for Alcohol Use

Summary

The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (AMP-A). These participants will be asked to provide both qualitative and quantitative input about the AMP-A intervention. Based on their input and clinician input, the AMP-A manual will be modified for use in Phase 2. The goal is to recruit up to 20 participants in order to ensure there will be at least 8 participants who complete all sessions of AMP-A. Phase 2 is a randomized clinical trial (RCT) protocol in which individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete AMP-A or an evidence-based cognitive-behavioral therapy (CBT) intervention. Up to 100 participants will be recruited in order to reach a target of N=60. Assessed outcomes will include participant acceptability and completion rates, participant compliance with the intervention, positive and negative affect, substance use- and depression and anxiety-related symptom severity, functional disability, and neural reactivity to reward and alcohol cues during functional magnetic resonance imaging (fMRI).

Conditions

• Alcohol Use Disorder
• Anxiety
• Depression

Interventions

BEHAVIORAL

Cognitive Behavioral Therapy

Cognitive Behavioral Therapy

BEHAVIORAL

Amplification of Positivity Therapy

Amplification of Positivity Therapy

BEHAVIORAL

Surveys and Interviews

Participants will answer questions regarding their mental and physical health as well as their substance use on the computer and in an interview format.

Sponsors & Collaborators

• University of California, San Diego

  collaborator OTHER

• National Institute on Alcohol Abuse and Alcoholism (NIAAA)

  collaborator NIH

• Laureate Institute for Brain Research, Inc.

  lead OTHER

Principal Investigators

• Robin L Aupperle, PhD · Laureate Institute for Brain Research

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-09-25

Primary Completion

2026-07-31

Completion

2026-07-31

Countries

• United States

Study Locations