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Sequence of Symptom Change During AUD or PTSD Treatment for Comorbid PTSD/AUD

NCT01663337 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 235

Last updated 2018-07-18

No results posted yet for this study

Summary

The broad, long-term objective of the current research is to improve treatment outcomes for individuals with comorbid posttraumatic stress disorder (PTSD) and alcohol abuse and dependence (AUD).

The purpose of which is to evaluate changes in both PTSD symptoms and alcohol use and cravings associated with Cognitive Processing Therapy (CPT) or Relapse Prevention (RP) treatment in individuals with PTSD/AUD, along with mediators and moderators of outcomes.

The study will randomize 235 PTSD/AUD participants recruited from the VA and from the community to CPT, RP, or Interactive Voice Response (IVR) assessment only (AO). Those in the AO condition will be re-randomized after the treatment phase to either RP or CPT. Individuals will be assessed pretreatment, immediately post-treatment, 3-, 6-, 9-, and 12-months post-treatment and will monitor symptoms daily throughout treatment.

Conditions

  • PTSD
  • Alcohol Abuse
  • Alcohol Dependence

Interventions

BEHAVIORAL

Cognitive Processing Therapy (CPT)

CPT is a highly structured course of therapy that focuses primarily on the cognitive restructuring of trauma related beliefs.

BEHAVIORAL

Relapse Prevention (RP)

RP utilizes high-risk situation assessment/avoidance, drink refusal skills, assertiveness training,cognitive restructuring as well as other approaches to address issues of alcohol use/dependance.

Sponsors & Collaborators

Principal Investigators

  • Debra Kaysen · Univeristy of Washington

  • Tracy Simpson · VA Puget Sound Health Care

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-03-31
Primary Completion
2018-09-30
Completion
2019-01-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01663337 on ClinicalTrials.gov