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PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery

NCT06021717 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2023-09-01

No results posted yet for this study

Summary

The goal of this clinical trial is to compare the effectiveness of PCA ketamine-morphine versus conventional PCA morphine in postoperative patients undergoing elective laparotomy colorectal surgery under general anaesthesia. The specific objectives are:

1. To compare the post-operative analgesic requirement with PCA ketamine-morphine in comparison with PCA morphine.
2. To compare the postoperative pain scores between PCA ketamine-morphine and PCA morphine.
3. To assess patients' overall satisfaction with PCA ketamine-morphine in comparison with PCA morphine.
4. To study the incidence of side effects of PCA ketamine-morphine in comparison with PCA morphine.

Participants will be screened and recruited at pre-anaesthetic clinic (PAC). Those who consented will be taught to use PCA machine and the potential side effects of the study drugs. They will be randomly allocated into either Group A or Group B by computer generated randomization a day before planned surgery.

Researchers will compare Group A and Group B to see post-operative pain scores, patients' overall satisfaction and any incidence of side effects.

Conditions

  • Ketamine
  • Morphine

Interventions

DRUG

Ketamine-Morphine

PCA ketamine (Ketamine HCl, Pfizer Inc., US) 0.5 mg plus morphine 0.5 mg ml-1 (ratio 1:1)

DRUG

Morphine

PCA morphine (Pfizer Inc., US) 1 mg ml-1

Sponsors & Collaborators

  • Universiti Kebangsaan Malaysia Medical Centre

    lead OTHER

Principal Investigators

  • Chian Yong Liu, MMed (Anaes) · Universiti Kebangsaan Malaysia Medical Centre

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-04-05
Primary Completion
2019-04-04
Completion
2019-04-04

Countries

  • Malaysia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06021717 on ClinicalTrials.gov