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The Effects of Two Anesthetic Drugs on Some Enzyme Levels in Patients Undergoing Lower Extremity Surgery

NCT05950555 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2023-08-31

No results posted yet for this study

Summary

The primary aim of this study was to compare the effects of dexmedetomidine and ketamine, which are administered intravenously during surgery, on the levels of malondialdehyde, an antioxidant, anti-inflammatory enzyme, heme oxygenase-1 enzyme levels and C-reactive protein levels in patients who underwent lower extremity surgery under combined spinal epidural anesthesia.

Conditions

  • Malondialdehyde
  • Heme Oxygenase
  • C-Reactive Protein

Interventions

OTHER

Saline

We used 0.9% isotonic sodium chloride.

OTHER

Dexmedetomidine

We used the vial containing 200 mcg/2 ml i.v. concentrated infusion solution in 100 ml of 0.9% isotonic sodium chloride.

OTHER

Ketamine

We used 500 mg/10 ml solution for injection in 0.9% isotonic sodium chloride.

Sponsors & Collaborators

  • Ataturk University

    lead OTHER

Principal Investigators

  • İrfan Uç · Research Assistant

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-12-30
Primary Completion
2023-03-30
Completion
2023-05-28

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05950555 on ClinicalTrials.gov