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Comparison of CRP Levels, Neutrophil Count, and Clinical Outcomes of Low Dose Ketamine Between at Anesthesia Induction and at the End of Surgery in Patients Undergo Elective Laparotomy

NCT04462094 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 68

Last updated 2020-11-12

No results posted yet for this study

Summary

The effects of anesthesia and surgery can lead to stress responses that result in hormonal and metabolic changes in the body. The immune system and the nervous system communicate both ways, and it was found that nociception and proinflammatory cytokines play a joint regulatory role, i.e., increased production of proinflammatory cytokines can worsen the pain. Major surgery can trigger the release of cytokines such as IL-1, IL-6, and TNF-α.

Conditions

Interventions

DRUG

Ketamine 0.3 mg/kg at end-of-surgery

Ketamine 0.3 mg/kg at end-of-surgery (intravenously)

DRUG

Ketamine 0.3 mg/kg at anesthesia induction

Ketamine 0.3 mg/kg at anesthesia induction (intravenously)

Sponsors & Collaborators

  • Udayana University

    lead OTHER

Principal Investigators

  • Tjokorda GA Senapathi, Dr · Udayana University

  • Christopher Ryalino, Dr · Udayana University

  • Made SP Adi, Dr · Udayana University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-07-27
Primary Completion
2020-09-30
Completion
2020-11-10

Countries

  • Indonesia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04462094 on ClinicalTrials.gov