Observational Study on "Functional Overlay" in Patients With Movement Disorders

Summary

The goal of this observational study is to learn about functional neurological disorders in patients with common non-functional movement disorders ("functional overlay"). The main questions it aims to answer are:

* What is the frequency of functional neurological disorders in patients with non-functional movement disorders (functional overlay)?
* What are the characteristics of functional neurological disorders in patients with non-functional movement disorders?

Participants will be examined clinically and electrophysiologically, the examinations consist of:

* a neurological examination
* neuropsychological testing
* electrophysiological tremor diagnostic
* questionnaires about psychological, biological and social risk factors

Researchers will compare patients with functional motor disorders to patients wit non-functional movement disorders to see if they differ from each other regarding the functional symptoms.

Conditions

• Conversion Disorder
• Parkinson Disease
• Tremor
• Dystonia

Interventions

DIAGNOSTIC_TEST

Neurological examination

A neurological examination following a protocol to detect positive signs of functional neurological disorders.

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Anamnesis

A standardized question about the patient´s history. The response time is measured. Question: "Could you tell me about the problems with the movement disorder you are experiencing?"

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Neuropsychological testing

Neuropsychological cognitive testing including: * Montreal Cognitive Assessment (MOCA) * Rey-Osterrieth Complex Figure Test (ROCFT) * Wechsler Memory Scale IV * Comprehensive Trail Making Test (CTMT) * semantic and phonematic fluency tests

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Questionnaires

* Short Form 36 (SF 36) * Somatic Symptom Disorder - B Criteria Scale (SSD 12) * Patient Health Questionnaire 9 (PHQ 9) * Patient Health Questionnaire 15 (PHQ 15) * Generalized Anxiety Disorder 7 (GAD 7) * Fatigue Severity Scale (FSS) * Psychosomatic Competence Inventory (PSCI) * Work Ability Index (WAI) * Level of Personality Functioning Scale * Toronto Alexithymia Scale * Levels of Emotional Awareness Scale (short version) * Certainty About Mental States Questionnaire * Somatosensoric Amplification Scale * Personality Inventory for DSM-5 short version (PID5BF+M) * Childhood Trauma Questionnaire * European Quality of Life 5 Dimensions 5 Level Version (EQ5D5L)

DIAGNOSTIC_TEST

Tremor recording

Accelerometry following a standardized protocol, using a triaxial accelerometer transducer (Biometrics ACL300, Sensitivity 6 100 mV/G, Biometrics Ltd, UK)

Sponsors & Collaborators

• Medical University of Graz

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-01-01

Primary Completion

2025-12-31

Completion

2026-06-30

Countries

• Austria

Study Locations