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Clinical and Physiological Studies of Tremor Syndromes

NCT03027310 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 85

Last updated 2026-05-22

No results posted yet for this study

Summary

Background:

Researchers have some data on how the brain controls movement and why some people have tremor. But the causes of tremor are not fully known. Researchers want to study people with tremor to learn about changes in the brain and possible causes of tremor.

Objective:

To better understand how the brain controls movement, learn more about tremor, and train movement disorder specialists.

Eligibility:

People ages 18 and older with a diagnosed tremor syndrome

Healthy volunteers ages 18 and older

Design:

Participants will be screened with:

* Medical history
* Physical exam
* Urine tests
* Clinical rating scales
* Health questions
* They may have electromyography (EMG) or accelerometry. Sensors or electrodes taped to the skin measure movement.

Participation lasts up to 1 year.

Some participants will have a visit to examine their tremor more. They may have rating scales, EMG, and drawing and writing tests.

Participants will be in 1 or more substudies. These will require up to 7 visits. Visits could include the following:

* EMG with accelerometry
* Small electrodes taped on the body give small electric shocks that stimulate nerves.
* MRI: Participants lie on a table that slides into a cylinder that takes pictures of the body while they do simple tasks.
* Small electrodes on the scalp record brain waves.
* A cone with detectors on the head measures brain activity while participants do tasks.
* A wire coil held on the scalp gives an electrical current that affects brain activity.
* Tests for thinking, memory, smell, hearing, or vision
* Electrodes on the head give a weak electrical current that affects brain activity.
* Photographs or videos of movement

Participant data may be shared with other researchers....

Conditions

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    lead NIH

Principal Investigators

  • Debra J Ehrlich, M.D. · National Institute of Neurological Disorders and Stroke (NINDS)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-05-05
Primary Completion
2022-03-23
Completion
2022-03-23

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03027310 on ClinicalTrials.gov