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ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis Approach

NCT05928416 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 653

Last updated 2026-03-27

No results posted yet for this study

Summary

RNALS is a multicentre, transversal, diagnostic and non-interventional study carried out in ALS reference centers; in order to identify a diagnostic signature for Amyotrophic Lateral Sclerosis by analyzing of coding and non-coding RNA contained in patients saliva.

The study population consists of patients with definite or probable amyotrophic lateral sclerosis (ALS) according to the El Escorial criteria ("ALS Subjects" group) and subjects with no neurological history (Control group).

The control group will be made up of caregivers of patients with ALS, and caregivers of patients with a pathology other than ALS.

The ALS patients concerned by the study already benefit from routine medical care in ALS expert centers in France.

The patients concerned by the study will be managed without modification of the care pathway, nor modification of the therapeutic indications, nor modification of the diagnostic or follow-up examinations necessary according to the context, which are carried out according to the recommendations of the HAS, CNGOF.

Conditions

Interventions

DIAGNOSTIC_TEST

Saliva sample

During the inclusion visit : * a neurological examination is taken * a saliva sample is taken

DIAGNOSTIC_TEST

Saliva sample

During the inclusion visit : * a saliva sample is taken

Sponsors & Collaborators

  • Monitoring Force Group

    collaborator INDUSTRY

  • ZIWIG

    lead INDUSTRY

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-11
Primary Completion
2025-11-18
Completion
2026-05-31

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05928416 on ClinicalTrials.gov