Answer ALS: Individualized Initiative for ALS Discovery

Summary

Creation of a large repository of induced pluripotent stem cells (iPSC), bio-fluid samples (blood and spinal fluid (optional)), and cell lines for ALS gene identification. This will be combined carefully with collected measures of the pattern of the symptoms people with ALS have and how these change over time. People with other motor neuron diseases and healthy controls will be included as comparisons

Conditions

• Amyotrophic Lateral Sclerosis
• Primary Lateral Sclerosis
• Flail Arm ALS
• Progressive Muscular Atrophy
• Monomelic Amyotrophy
• Motor Neuron Disease
• Asymptomatic ALS Gene Carriers
• Healthy Controls

Sponsors & Collaborators

• Massachusetts General Hospital

  collaborator OTHER

• Emory University

  collaborator OTHER

• Ohio State University

  collaborator OTHER

• Washington University School of Medicine

  collaborator OTHER

• Cedars-Sinai Medical Center

  collaborator OTHER

• University of California, Irvine

  collaborator OTHER

• Massachusetts Institute of Technology

  collaborator OTHER

• New York Genome Center

  collaborator OTHER

• Leandro P. Rizzuto Foundation

  collaborator OTHER

• Texas Neurology

  collaborator UNKNOWN

• Northwestern University Les Turner ALS Center

  collaborator UNKNOWN

• Johns Hopkins University

  lead OTHER

Principal Investigators

• Nicholas J Maragakis, MD · Johns Hopkins University

• James D Berry, MD · Massachusetts Generel Hospital

Eligibility

Min Age

18 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-12-31

Primary Completion

2019-12-31

Completion

2020-01-01

Countries

• United States

Study Locations