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Novel Diagnostic Methods to Identify External Ventricular Drain Associated Infections

NCT05904535 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2023-06-15

No results posted yet for this study

Summary

External ventricular drain infections are difficult to identify with current diagnostic methods. Initiation of antibiotic treatment is usually supported by indirect methods of bacterial infection, such as clinical signs or cerebrospinal fluid cell counts (CSF). As such, excessive treatment with antibiotics is common in these patients due to suspected infection while the incidence of true culture confirmed infections are less common. This study will evaluate three novel diagnostic methods for rapid direct bacterial detection in CSF, in order to assess if these can be used to guide antibiotic treatment in neurocritically ill patients, compared to CSF bacterial cultures.

Conditions

  • Ventricular Drain Related Infection
  • Nosocomial Infection
  • Infection, Bacterial
  • Ventriculitis, Infectious

Interventions

OTHER

Cerbrospinal fluid sampling.

Routine sampling of cerebrospinal fluid from the proximal external ventricular drain port.

Sponsors & Collaborators

  • Region Stockholm

    collaborator OTHER_GOV

  • Karolinska Institutet

    collaborator OTHER

  • Karolinska University Hospital

    lead OTHER

Principal Investigators

  • David W Nelson, MD, PhD · Karolinska University Hospial, Karolinska Institutet

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-21
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • Sweden

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05904535 on ClinicalTrials.gov