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Myocardial Injury and Dysfunction Associated With COVID-19 Vaccination

NCT05359250 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2025-04-04

No results posted yet for this study

Summary

The overall goal of the study is to investigate the characteristics and potential mechanisms responsible for myocardial injury and dysfunction in patients after COVID-19 vaccination. Cardiac damage will be assessed with cardiac MRI and endomyocardial biopsy (EmBx) histopathology. Myocardial gene expression will be measured in RNA extracted from EmBxs mRNA abundance compared to nonfailing and failing control hearts.

Conditions

  • Myocardial Injury
  • COVID-19
  • Vaccine Reaction

Sponsors & Collaborators

  • American Heart Association

    collaborator OTHER

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • University of Colorado, Denver

    lead OTHER

Principal Investigators

  • Natasha Altman, MD · University of Colorado, Denver

  • Bristow Michael, MD/PhD · University of Colorado, Denver

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-12
Primary Completion
2024-12-30
Completion
2024-12-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05359250 on ClinicalTrials.gov