MedTrace Logo

The Relationship of RAGE Gene Polymorphism With Type I Diabetes in Egyptian Patients

NCT05874323 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 354

Last updated 2023-08-23

No results posted yet for this study

Summary

Type I Diabetes Mellitus (TIDM) is a chronic metabolic disorder caused by the immune-mediated T-cell and macrophages that typically affects insulin-producing β-cells of Langerhans leading to cell destruction and absolute insulin deficiency. This study aimed to investigate the correlation of RAGE gene polymorphism rs1800625 with the incidence of type I diabetes mellitus in the Egyptian patients with the activity and the severity of the disease and to assess their association with inflammatory reactions in TIDM patients (IL-6, TNF-α). Also, this study investigated the relation between MiRNA-34, MiRNA-146, to TID severity and activity

Conditions

  • Type1diabetes

Interventions

GENETIC

Detection of RAGE gene polymorphism (rs1800625)

Detection of RAGE gene polymorphism (rs1800625) By Molecular analysis (real time PCR)

Sponsors & Collaborators

  • Future University in Egypt

    lead OTHER

Principal Investigators

  • Amal mohamed, professor · national hepatology and Tropical medicine institute

Study Design

Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2023-05-10
Completion
2023-05-10

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05874323 on ClinicalTrials.gov