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Methylation of DNA in Children and Adolescents With Type 1 Diabetes Mellitus (METHYLDIAB)

NCT04139369 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2019-10-25

No results posted yet for this study

Summary

Type 1 Diabetes Mellitus (T1DM) is a well-studied autoimmune disease resulting in insulin deficiency due to selective β-cell destruction. Epigenetics is a novel field of biology studying the inherited changes in deoxyribonucleic acid (DNA) expression which cannot be attributed to base sequence alteration. A relatively limited number of studies are published until now concerning T1DM in children and adolescents addressing epigenetics changes in DNA expression. The purpose of the present study is to analyze the methylation status of DNA within the promoter region of specific susceptibility genes such as Protein tyrosine phosphatase, non-receptor type 22 (PTPN-22), Insulin (INS) and Human leukocyte antigen G (HLA-G) genes.

Conditions

  • Type 1 Diabetes Mellitus

Sponsors & Collaborators

  • Aristotle University Of Thessaloniki

    lead OTHER

Principal Investigators

  • Assimina Galli-Tsinopoulou, MD,PhD · Unit of Pediatric Endocrinology/Diabetes/Metabolism 4thDepartment of Pediatrics

Eligibility

Min Age
2 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-05-31
Primary Completion
2015-05-31
Completion
2018-08-31

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04139369 on ClinicalTrials.gov