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Assessment of PaO2/FiO2 Ratio Pre and POst INTubation

NCT05853068 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2025-08-26

No results posted yet for this study

Summary

We designed this study to dtermine whether invasive mechanical ventilation (MV) would have an impact on the reclassification of patients with acute hypoxemic respiratory failure (AHRF) -treated previously with non-invasive respiratory support- into categories of severity (mild, moderate, and severe). Our hypothesis is that the assessment of PaO2/FiO2 ratio on PEEP greater or equal to 5 cmH2O after intubation, in patients labeled as mild/moderate/severe AHRF while on non-invasive respiratory support, would identify that a marked proportion of patients would change the degree of severity after a brief period of invasive MV

Conditions

  • Acute Hypoxemic Respiratory Failure

Interventions

DEVICE

Mechanical ventilation

Need for endotracheal intubation and invasive mechanical ventilation

Sponsors & Collaborators

  • Rush University Medical Center

    collaborator OTHER

  • Dr. Negrin University Hospital

    lead OTHER

Principal Investigators

  • Jesús Villar · Hospital Universitario D. Negrin

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-29
Primary Completion
2025-11-30
Completion
2025-11-30

Countries

  • United States
  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05853068 on ClinicalTrials.gov