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Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS

NCT05852405 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2000

Last updated 2025-01-29

No results posted yet for this study

Summary

Patients with sporadic ALS (sALS), which refers to those without a family history of ALS, are typically not subjected to genetic investigations as part of their standard care. Therefore, their mutation status is often unknown. Even patients with familial ALS (fALS), who have a known family history of ALS, are not regularly screened for genetic mutations. This project aims to study a large group of ALS patients, examining their family history, clinical characteristics, healthcare measures, and genetic variants in ALS's most commonly mutated genes: SOD1, C9orf72, FUS, and TARDBP. Examining genetically distinct ALS cohorts is significant, as understanding the relationship between genotype and disease progression is essential in determining the therapeutic potential of future genetic therapies.

Conditions

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sponsors & Collaborators

  • Charite University, Berlin, Germany

    collaborator OTHER

  • Ambulanzpartner Soziotechnologie APST GmbH

    lead INDUSTRY

Principal Investigators

  • Thomas Meyer, Prof. Dr. · Center for ALS and other motor neuron disorders, Charité - Universitätsmedizin Berlin

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-01
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05852405 on ClinicalTrials.gov