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Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety

NCT05843695 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 306

Last updated 2026-02-03

No results posted yet for this study

Summary

The goal of this clinical trial is to compare two different intensive formats of delivering cognitive-behavioral treatment for people with PTSD and anxiety disorders. The main questions it aims to answer are:

* Is iTCBT delivered in individual and group formats more effective than TAU in improving anxiety symptoms and quality of life?
* For treatment non-responders, is iTCBT-Enhanced more effective than TAU improving anxiety symptoms and quality of life?
* Does iTCBT-Individual produce a larger improvement in anxiety and quality of life compared with iTCBT-Group?

Participants will undergo several assessments throughout the course of the study. Based on randomization, they will receive: (1) iTCBT in an individual format over a 2-week period, (2) iTCBT in a group format over a 2-day period, or (3) usual care. Those who do not show a response to treatment will receive 4 additional individual therapy sessions.

Conditions

Interventions

BEHAVIORAL

iTCBT-I

Individual format over 2 weeks

BEHAVIORAL

iTCBT-G

Group format over 2 days

BEHAVIORAL

TAU

Standard care

Sponsors & Collaborators

  • United States Department of Defense

    collaborator FED

  • Baylor College of Medicine

    lead OTHER

Principal Investigators

  • Ellen Teng, PhD · Michael E. DeBakey VA Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-22
Primary Completion
2027-03-30
Completion
2027-03-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05843695 on ClinicalTrials.gov