Project Remission: Maximizing Outcomes With Intensive Treatments for Combat-Related PTSD

Summary

The study compares two intensive outpatient behavioral programs (Massed Prolonged Exposure versus Intensive Outpatient Prolonged Exposure) for the treatment of posttraumatic stress disorder (PTSD) in post-9/11 active duty service members and veterans. The researchers hope to learn if these programs improve treatment outcomes. The researchers predict that Intensive Outpatient Prolonged Exposure (IOP-PE) will be better at treating PTSD than Massed-Prolonged Exposure (Massed PE).

Conditions

• Posttraumatic Stress Disorder (PTSD)

Interventions

BEHAVIORAL

Massed Prolonged Exposure

Participants will complete fifteen weekday 90-minute Prolonged Exposure therapy sessions over three consecutive weeks. If necessary, the treatment window may be extended for another week.

BEHAVIORAL

Intensive Outpatient Prolonged Exposure

The IOP-PE will include the same primary treatment components as the Massed-PE protocol (fifteen weekday 90-minute PE sessions delivered five days a week over a three-week period) plus eight augmentations designed to maximize treatment outcomes. Similar to the Mass-PE, participants will have three consecutive weeks to complete treatment; however, the treatment window may be extended another week if necessary.

Sponsors & Collaborators

• Brooke Army Medical Center

  collaborator FED

• South Texas Veterans Health Care System

  collaborator FED

• C.R.Darnall Army Medical Center

  collaborator FED

• Central Texas Veterans Health Care System

  collaborator OTHER

• VISN 17 Center of Excellence

  collaborator FED

• University of Pennsylvania

  collaborator OTHER

• The University of Texas Health Science Center at San Antonio

  lead OTHER

Principal Investigators

• Alan L Peterson, PhD · University of Texas Health Science Center at San Antonio; South Texas Veterans Health Care System

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-01-27

Primary Completion

2019-11-22

Completion

2021-05-01

Countries

• United States

Study Locations